Amyloid-beta (Aβ) is a collection of peptide fragments derived from cleavage of amyloid precursor protein (APP). Some of these fragments are toxic to neurons and aggregate forming oligomers and fibrils. These clusters of Aβ form plaques that accumulate in the brains of people with dementia due to Alzheimer’s disease (Figure 1). Preventing the accumulation of … Read moreTargeting Pyroglutamate Aβ in Alzheimer’s Disease
A vaccine may be described as medicine that stimulates an immune response with a “memory.” Many people also consider a vaccine to be a medicine that prevents a disease caused by a pathogen. Indeed, the first vaccines were ones that prevented infectious diseases, such as polio and measles. Some vaccines have been so successful that … Read moreCan you be vaccinated against yourself?