Immunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Unlike osteoarthritis, rheumatoid arthritis is an autoimmune disease (1). The body’s own immune system attacks the joints, causing swelling, pain, heat, redness, immobility, and tissue damage that can cause deformation (Figure 1). Because rheumatoid arthritis is an autoimmune disease, some types of immunomodulatory agents are specifically useful for treating this condition. Although both types of arthritis … Read moreImmunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Stem Cell Injections for Osteoarthritic Knees

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Some friends recently asked me about getting stem cell injections for painful knees with osteoarthritis (Figure 1). Should they push their doctors for this treatment? Were they, and consequently their stem cells, going to be too old if they waited? I started my investigation at PubMed, searching for “stem cells” and “osteoarthritis,” which produced 1249 … Read moreStem Cell Injections for Osteoarthritic Knees

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No Prescription Required but Maybe Needed?

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Given the current opioid crisis, I have been wondering about how the situation got where it is today. As someone who lives with chronic pain due to a neuropathy resulting from abdominal surgery, I can relate to the anxiety and fear associated with knowing you will be in pain and that you need medicine to … Read moreNo Prescription Required but Maybe Needed?

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Will zinc prevent or reduce a cold?

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A friend with kids who just went back to school asked me about using various zinc products to reduce the length of or prevent the common cold. Years ago, I tried the nasal swab version of one of these products (Zicam) and was amazed at how painful they were. This prompted me to research the … Read moreWill zinc prevent or reduce a cold?

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Targeting Pyroglutamate Aβ in Alzheimer’s Disease

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Amyloid-beta (Aβ) is a collection of peptide fragments derived from cleavage of amyloid precursor protein (APP). Some of these fragments are toxic to neurons and aggregate forming oligomers and fibrils. These clusters of Aβ form plaques that accumulate in the brains of people with dementia due to Alzheimer’s disease (Figure 1). Preventing the accumulation of … Read moreTargeting Pyroglutamate Aβ in Alzheimer’s Disease

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