Blocking Nuclear Translocation to Treat Cancer and Colitis

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Many proteins have multiple roles. Often, the key to effective therapy is specificity. Not only does the treatment need to be specific for a particular physiological target, often a protein, but the therapeutic effects involve only a single function or subset of the target’s functions or needs to affect the target only within a specific … Read moreBlocking Nuclear Translocation to Treat Cancer and Colitis

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Immunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Unlike osteoarthritis, rheumatoid arthritis is an autoimmune disease (1). The body’s own immune system attacks the joints, causing swelling, pain, heat, redness, immobility, and tissue damage that can cause deformation (Figure 1).¬†Because rheumatoid arthritis is an autoimmune disease, some types of immunomodulatory agents are specifically useful for treating this condition. Although both types of arthritis … Read moreImmunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Stem Cell Injections for Osteoarthritic Knees

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Some friends recently asked me about getting stem cell injections for painful knees with osteoarthritis (Figure 1). Should they push their doctors for this treatment? Were they, and consequently their stem cells, going to be too old if they waited? I started my investigation at PubMed, searching for “stem cells” and “osteoarthritis,” which produced 1249 … Read moreStem Cell Injections for Osteoarthritic Knees

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