Given the current opioid crisis, I have been wondering about how the situation got where it is today. As someone who lives with chronic pain due to a neuropathy resulting from abdominal surgery, I can relate to the anxiety and fear associated with knowing you will be in pain and that you need medicine to … Read moreNo Prescription Required but Maybe Needed?
Amyloid-beta (Aβ) is a collection of peptide fragments derived from cleavage of amyloid precursor protein (APP). Some of these fragments are toxic to neurons and aggregate forming oligomers and fibrils. These clusters of Aβ form plaques that accumulate in the brains of people with dementia due to Alzheimer’s disease (Figure 1). Preventing the accumulation of … Read moreTargeting Pyroglutamate Aβ in Alzheimer’s Disease
Toxicity to healthy cells limits the usefulness of conventional chemotherapeutic agents. These drugs kill rapidly dividing cells of all types, not just those in a tumor. In addition to dividing rapidly, some cancer cells establish metastases that have a different stiffness than the surrounding tissue. This mechanical property of a cellular microenvironment is referred to … Read moreLeveraging Cellular Mechanical Signaling to Improve Drug Specificity