TGF-β and Wnt Signaling Challenge the Concept of ‘a’ Pathway

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Researchers commonly refer to the molecular and biochemical events that occur in response to extracellular signals as pathways. There is a tendency to lump a related set of pathways into a general overarching pathway. For example, researchers may refer to the TGF-β pathway or the Wnt pathway. These are no more individual pathways than the … Read moreTGF-β and Wnt Signaling Challenge the Concept of ‘a’ Pathway

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Drug Repurposing: Preserving Vision with New Drug Combinations

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Overcoming side effects and toxicity of currently FDA-approved is possible. Sometimes combining multiple drugs with different mechanisms of action lets doctors use less of each drug to achieve the desired effect and limit or avoid off-target or dose-limiting effects. This is a common strategy used for anesthesia. Doctors give a “cocktail” of drugs with different … Read moreDrug Repurposing: Preserving Vision with New Drug Combinations

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