SRC on the Outside

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Secreted proteins or the parts of transmembrane proteins that are extracellular can be phosphorylated. DeRita and colleagues reported that the cytosolic tyrosine kinase c-SRC was one of several kinases released from prostate cancer cells in exosomes. Sánchez-Pozo and colleagues identified a cancer-relevant function for extracellular c-SRC: c-SRC functioned outside of cultured cells to regulate the … Read moreSRC on the Outside

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Cancer-Protective Bacteria Found on Human Skin

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Researchers find that a bacterial species present on healthy skin produce a chemical that prevents skin cancer. Humans can be considered metaorganisms.  Our bodies includes billions of microorganisms.  There are microbes in the gastrointestinal (GI) system (referred to as the gut microbiome), on the skin, in the nose and eyes, and in the parts of … Read moreCancer-Protective Bacteria Found on Human Skin

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Intratumor Immunotherapy Kills Injected and Distant Tumors

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Cancerous tumors must evade immune destruction to survive. They can achieve this by preventing the immune cells from gaining access to the tumor (“immune cold”) or by tipping the balance of immunoactivating and immunosuppressing signals toward immunosuppression. Immunosuppression means that, even if the immune cells penetrate the tumor, they cannot kill the cancer. The cytotoxicity … Read moreIntratumor Immunotherapy Kills Injected and Distant Tumors

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