The Central Role of Mitochondria in Red Blood Cells

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Ferrochelatase in heme biosynthesis Ferrochelatase (FECH) is an enzyme found in mitochondria that adds iron ions (Fe2+) into protoporphyrin to produce heme (Figure 1). This biochemical reaction is critical for cell health.  The process is tightly controlled so that cells produce the amount of heme needed and do not accumulate too much of the heme … Read moreThe Central Role of Mitochondria in Red Blood Cells

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Drug Repurposing: Preventing Blindness with an Antifungal

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Benefits of Off-Target Effects There are many FDA-approved medicines. Most have some “off-target” effects, meaning effects that are not those intended for the drug. Sometimes these off-target effects limit the dose of a drug that can be used to treat the intended disease or symptom.  Sometimes these off-target effects are unwanted side effects that the … Read moreDrug Repurposing: Preventing Blindness with an Antifungal

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The Power of Proteomics in Medicine

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  Although genomic (DNA) and transcriptomic (messenger RNA) data are easier to collect and analyze, these are only two of the relevant types of “omic” data that are important for understanding disease and the response to treatments. Proteomic, metabolomic, and lipidomic data are also contain information that can be used diagnostically, prognostically, in developing treatment … Read moreThe Power of Proteomics in Medicine

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Single-Cell Proteomics Shines Light on the Complexity of Immune Cells in Solid Tumors

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A Proteomic Approach to the Tumor Microenvironment An outstanding issue in treating solid cancers is understanding the complexity of this pathological tissue. Solid tumors are comprised not only of the cancer cells, but they also contain immune cells, cells that form blood vessels and lymphatic vessels, fibroblasts, and the stem cells that form the fibroblasts … Read moreSingle-Cell Proteomics Shines Light on the Complexity of Immune Cells in Solid Tumors

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The Power of Proteomics in Building the Human Protein Interaction Network

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Defining >56,000 Human Protein Interactions through Mass Spectrometry Huttlin and colleagues applied mass spectrometric analysis to affinity purified protein complexes to help build a partial reference map of the human protein interaction space (1). The cDNA encoding the target proteins also engineered to have affinity tags (hemagglutinin and FLAG) were introduced into an easily infected … Read moreThe Power of Proteomics in Building the Human Protein Interaction Network

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