Immunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Unlike osteoarthritis, rheumatoid arthritis is an autoimmune disease (1). The body’s own immune system attacks the joints, causing swelling, pain, heat, redness, immobility, and tissue damage that can cause deformation (Figure 1). Because rheumatoid arthritis is an autoimmune disease, some types of immunomodulatory agents are specifically useful for treating this condition. Although both types of arthritis … Read moreImmunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Engineering the Immune System to Treat Diabetes

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Some diseases arise because the immune system reacts with normal, healthy cells in the body. In other diseases, lack of an effective immune response contributes to the disease. Cancer cells escape attack by the immune system, in part, by producing a lot of the protein PD-L1 (Gough, 24 May 2017). PD-L1 binds and activates the … Read moreEngineering the Immune System to Treat Diabetes

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Targeting Pyroglutamate Aβ in Alzheimer’s Disease

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Amyloid-beta (Aβ) is a collection of peptide fragments derived from cleavage of amyloid precursor protein (APP). Some of these fragments are toxic to neurons and aggregate forming oligomers and fibrils. These clusters of Aβ form plaques that accumulate in the brains of people with dementia due to Alzheimer’s disease (Figure 1). Preventing the accumulation of … Read moreTargeting Pyroglutamate Aβ in Alzheimer’s Disease

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Can you be vaccinated against yourself?

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A vaccine may be described as medicine that stimulates an immune response with a “memory.” Many people also consider a vaccine to be a medicine that prevents a disease caused by a pathogen. Indeed, the first vaccines were ones that prevented infectious diseases, such as polio and measles. Some vaccines have been so successful that … Read moreCan you be vaccinated against yourself?

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New Hope for Lyme Disease Prevention

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Lyme disease is caused by bacteria (Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii) that are delivered by a bite from an infected tick (Figure 1). The Centers for Disease Control (1) recommend a preventative (prophylactic) single dose of the antibiotic doxycycline for adults bitten by a mosquito with a high probability of carrying the Lyme-causing … Read moreNew Hope for Lyme Disease Prevention

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