Blocking Nuclear Translocation to Treat Cancer and Colitis

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Many proteins have multiple roles. Often, the key to effective therapy is specificity. Not only does the treatment need to be specific for a particular physiological target, often a protein, but the therapeutic effects involve only a single function or subset of the target’s functions or needs to affect the target only within a specific … Read moreBlocking Nuclear Translocation to Treat Cancer and Colitis

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Immunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Unlike osteoarthritis, rheumatoid arthritis is an autoimmune disease (1). The body’s own immune system attacks the joints, causing swelling, pain, heat, redness, immobility, and tissue damage that can cause deformation (Figure 1).¬†Because rheumatoid arthritis is an autoimmune disease, some types of immunomodulatory agents are specifically useful for treating this condition. Although both types of arthritis … Read moreImmunomodulators for Arthritis: Small-Molecule Disease-Modifying Agents

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Engineering the Immune System to Treat Diabetes

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Some diseases arise because the immune system reacts with normal, healthy cells in the body. In other diseases, lack of an effective immune response contributes to the disease. Cancer cells escape attack by the immune system, in part, by producing a lot of the protein PD-L1 (Gough, 24 May 2017). PD-L1 binds and activates the … Read moreEngineering the Immune System to Treat Diabetes

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