Single-Cell Proteomics Shines Light on the Complexity of Immune Cells in Solid Tumors

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A Proteomic Approach to the Tumor Microenvironment An outstanding issue in treating solid cancers is understanding the complexity of this pathological tissue. Solid tumors are comprised not only of the cancer cells, but they also contain immune cells, cells that form blood vessels and lymphatic vessels, fibroblasts, and the stem cells that form the fibroblasts … Read moreSingle-Cell Proteomics Shines Light on the Complexity of Immune Cells in Solid Tumors

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The Power of Proteomics in Building the Human Protein Interaction Network

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Defining >56,000 Human Protein Interactions through Mass Spectrometry Huttlin and colleagues applied mass spectrometric analysis to affinity purified protein complexes to help build a partial reference map of the human protein interaction space (1). The cDNA encoding the target proteins also engineered to have affinity tags (hemagglutinin and FLAG) were introduced into an easily infected … Read moreThe Power of Proteomics in Building the Human Protein Interaction Network

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The Power of Proteomics in Vascular Disease

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This commentary on the power of proteomics highlights research showing how proteomics can advance the diagnosis of atherosclerosis, a type of vascular disease. Langley and colleagues use mass spectrometric analysis to define a 4-protein signature that predicts patients with atherosclerosis who are at risk for a vascular event, such as stroke or heart attack.This study … Read moreThe Power of Proteomics in Vascular Disease

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