Blocking Nuclear Translocation to Treat Cancer and Colitis

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Many proteins have multiple roles. Often, the key to effective therapy is specificity. Not only does the treatment need to be specific for a particular physiological target, often a protein, but the therapeutic effects involve only a single function or subset of the target’s functions or needs to affect the target only within a specific … Read moreBlocking Nuclear Translocation to Treat Cancer and Colitis

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Writing Tips: First Impressions- Titles, Abstracts, and Cover Letters

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For 17 years as an editor, I had the pleasure of reading great manuscripts and the pain of reading poorly presented ones. The first parts of the manuscript that the editor sees are the title, abstract, and cover letter. So, it is essential to devote time and effort to crafting these with both the expert … Read moreWriting Tips: First Impressions- Titles, Abstracts, and Cover Letters

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Secreted Kinases May Promote Malignancy

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Protein kinases are enzymes that add phosphate groups onto specific amino acids on proteins. Most of these enzymes are active within cells. Kinases are often encoded by oncogenes, and aberrant activity of these regulatory enzymes is frequently associated with cancer. Data are emerging that kinases can also be released from cells. These secreted kinases can … Read moreSecreted Kinases May Promote Malignancy

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