SRC on the Outside

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Secreted proteins or the parts of transmembrane proteins that are extracellular can be phosphorylated. DeRita and colleagues reported that the cytosolic tyrosine kinase c-SRC was one of several kinases released from prostate cancer cells in exosomes. Sánchez-Pozo and colleagues identified a cancer-relevant function for extracellular c-SRC: c-SRC functioned outside of cultured cells to regulate the … Read moreSRC on the Outside

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The Central Role of Mitochondria in Red Blood Cells

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Ferrochelatase in heme biosynthesis Ferrochelatase (FECH) is an enzyme found in mitochondria that adds iron ions (Fe2+) into protoporphyrin to produce heme (Figure 1). This biochemical reaction is critical for cell health.  The process is tightly controlled so that cells produce the amount of heme needed and do not accumulate too much of the heme … Read moreThe Central Role of Mitochondria in Red Blood Cells

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