Amyloid precursor protein (APP) is best known as the protein that is cleaved to form the plaque-associated protein in the brains of Alzheimer’s patients. The APP gene encodes multiple alternatively spliced mRNA forms. The form that encodes a protein of 695 amino acids (APP695) is expressed in neurons. The transcript that encodes a 770 amino … Read moreSoluble Amyloid Precursor Protein Signals to Neural Stem Cells
A recent conversation inspired me to start the series: “In case you were wondering.” This is the first post in the series. We were discussing how people can exhibit different sensitivities to medicines, either the desired effect or side effects. The example that my relative used was the difference in children’s responses to local anesthetics, … Read moreWhy put epinephrine in local anesthetics?
Benefits of Off-Target Effects There are many FDA-approved medicines. Most have some “off-target” effects, meaning effects that are not those intended for the drug. Sometimes these off-target effects limit the dose of a drug that can be used to treat the intended disease or symptom. Sometimes these off-target effects are unwanted side effects that the … Read moreDrug Repurposing: Preventing Blindness with an Antifungal
Although genomic (DNA) and transcriptomic (messenger RNA) data are easier to collect and analyze, these are only two of the relevant types of “omic” data that are important for understanding disease and the response to treatments. Proteomic, metabolomic, and lipidomic data are also contain information that can be used diagnostically, prognostically, in developing treatment … Read moreThe Power of Proteomics in Medicine
This commentary on the power of proteomics highlights research showing how proteomics can advance the diagnosis of atherosclerosis, a type of vascular disease. Langley and colleagues use mass spectrometric analysis to define a 4-protein signature that predicts patients with atherosclerosis who are at risk for a vascular event, such as stroke or heart attack.This study … Read moreThe Power of Proteomics in Vascular Disease