Secreted Kinases May Promote Malignancy

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Protein kinases are enzymes that add phosphate groups onto specific amino acids on proteins. Most of these enzymes are active within cells. Kinases are often encoded by oncogenes, and aberrant activity of these regulatory enzymes is frequently associated with cancer. Data are emerging that kinases can also be released from cells. These secreted kinases can … Read moreSecreted Kinases May Promote Malignancy

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Intratumor Immunotherapy Kills Injected and Distant Tumors

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Cancerous tumors must evade immune destruction to survive. They can achieve this by preventing the immune cells from gaining access to the tumor (“immune cold”) or by tipping the balance of immunoactivating and immunosuppressing signals toward immunosuppression. Immunosuppression means that, even if the immune cells penetrate the tumor, they cannot kill the cancer. The cytotoxicity … Read moreIntratumor Immunotherapy Kills Injected and Distant Tumors

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