Cellular and whole-body metabolism changes with age. An emerging idea is that preventing these metabolic changes may reduce negative effects of aging or at least delay them. Indeed, this idea is popular enough that companies are developing and selling dietary supplements intended to boost “healthy” metabolism. Many are intended to boost the amount of a … Read more
Secreted proteins or the parts of transmembrane proteins that are extracellular can be phosphorylated. DeRita and colleagues reported that the cytosolic tyrosine kinase c-SRC was one of several kinases released from prostate cancer cells in exosomes. Sánchez-Pozo and colleagues identified a cancer-relevant function for extracellular c-SRC: c-SRC functioned outside of cultured cells to regulate the … Read more
Ferrochelatase in heme biosynthesis Ferrochelatase (FECH) is an enzyme found in mitochondria that adds iron ions (Fe2+) into protoporphyrin to produce heme (Figure 1). This biochemical reaction is critical for cell health. The process is tightly controlled so that cells produce the amount of heme needed and do not accumulate too much of the heme … Read more