I have known many people, including my own mother, who suffered from heartburn or gastro-esophageal reflux disease (GERD). Frequently, they complain of pain at night and have wondered why they would have pain at night when they are not eating. The simple answer is that there is a surge of acid production by the stomach … Read moreWhy is heartburn common at night?
Target tissue type, as well as a patient’s gender, nutritional, and reproductive status, must be considered to manipulate signaling through the RANKL/RANK pathway for therapeutic benefit. In some contexts, activating this pathway can be beneficial and in others inhibiting this pathway is beneficial. RANKL is the ligand, RANK [receptor activator of nuclear factor kappa-B (NF-κB)] … Read moreTherapeutic Applications for Inhibitors and Activators of RANKL/RANK Signaling