Some friends recently asked me about getting stem cell injections for painful knees with osteoarthritis (Figure 1). Should they push their doctors for this treatment? Were they, and consequently their stem cells, going to be too old if they waited? I started my investigation at PubMed, searching for “stem cells” and “osteoarthritis,” which produced 1249 … Read moreStem Cell Injections for Osteoarthritic Knees
Some cancer immunotherapy drugs turn off a signaling pathway; others turn on a signaling pathway (1). FDA-approved immunotherapy drugs that target the PD-L1/PD-1 or CTLA-4/B-7 immune checkpoints function as antagonists to block immune signaling pathways. Investigational immunotherapy drugs that target GITRL/GITR function as agonists to activate an immune signaling pathway. Investigational drugs that target OX40L/OX40 … Read moreImmunotherapy Antagonists and Agonists
From Osteoporosis to Breast Cancer Denosumab, a biologic agent, and bisphosphonates, which are small molecule drugs, reduce fractures that are complications of osteoporosis, including those caused by breast cancer hormone therapies that block estrogen signaling, menopause, or surgically-induced menopause (oophorectomy with or without hysterectomy). Both denosumab and bisphosphonates also reduce the risk of bone metastasis … Read moreCan Denosumab Prevent Breast Cancer?