Worth a Closer Look: May 2019

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26 May 2019

J Cell Physiol. 2019 May 20. doi: 10.1002/jcp.28769. From clinic to mechanism: Proteomics-based assessment of angiogenesis in adrenal pheochromocytoma. https://www.ncbi.nlm.nih.gov/pubmed/31106414

Pediatr Res. 2019 May 21. doi: 10.1038/s41390-019-0436-2. LCK rs10914542-G allele associates with type 1 diabetes in children via T cell hyporesponsiveness. https://www.ncbi.nlm.nih.gov/pubmed/31112992

JCI Insight. 2019 May 21;5. pii: 128496. doi: 10.1172/jci.insight.128496. The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing. https://www.ncbi.nlm.nih.gov/pubmed/31112528

J Neurotrauma. 2019 May 24. doi: 10.1089/neu.2019.6415. Traumatic Brain Injury Temporal Proteome Guides KCC2-targeted Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31122143

Genes Brain Behav. 2019 May 23. doi: 10.1111/gbb.12583. Novel Biomarkers to Assess In-Utero Effects of Maternal Opioid Use: First Steps towards Understanding Short and Long Term Neurodevelopmental Sequelae. https://www.ncbi.nlm.nih.gov/pubmed/31119847

Medicina (Kaunas). 2019 May 23;55(5). pii: E195. doi: 10.3390/medicina55050195. Preliminary Work Towards Finding Proteins as Potential Vaccine Candidates for Vibrio cholerae Pakistani Isolates through Reverse Vaccinology. https://www.ncbi.nlm.nih.gov/pubmed/31126058

EMBO J. 2019 May 22. pii: e101174. doi: 10.15252/embj.2018101174. Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling. https://www.ncbi.nlm.nih.gov/pubmed/31118249

J Tissue Eng. 2019 May 2;10:2041731419845852. doi: 10.1177/2041731419845852. 3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation. https://www.ncbi.nlm.nih.gov/pubmed/31105928

Onco Targets Ther. 2019 Apr 29;12:3197-3205. doi: 10.2147/OTT.S192218. Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling. https://www.ncbi.nlm.nih.gov/pubmed/31118672

J Cell Biol. 2019 Jun 3;218(6):2035-2050. doi: 10.1083/jcb.201810134. Comprehensive knockout analysis of the Rab family GTPases in epithelial cells. https://www.ncbi.nlm.nih.gov/pubmed/31072826

J Cell Biol. 2019 May 23. pii: jcb.201901096. doi: 10.1083/jcb.201901096. TORC2 controls endocytosis through plasma membrane tension. https://www.ncbi.nlm.nih.gov/pubmed/31123183

J Cell Biol. 2019 Jun 3;218(6):1972-1993. doi: 10.1083/jcb.201807068. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. https://www.ncbi.nlm.nih.gov/pubmed/31076452

Elife. 2019 May 28;8. pii: e40226. doi: 10.7554/eLife.40226. Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. https://www.ncbi.nlm.nih.gov/pubmed/31134894

Elife. 2019 May 16;8. pii: e43747. doi: 10.7554/eLife.43747. Stem cell topography splits growth and homeostatic functions in the fish gill. https://www.ncbi.nlm.nih.gov/pubmed/31090541

J Clin Invest. 2019 May 13;130:2485-2499. doi: 10.1172/JCI125646. Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. https://www.ncbi.nlm.nih.gov/pubmed/31081799

19 May 2019

Alzheimers Dement (Amst). 2019 May 2;11:374-382. doi: 10.1016/j.dadm.2019.03.001. Potential two-step proteomic signature for Parkinson’s disease: Pilot analysis in the Harvard Biomarkers Study. https://www.ncbi.nlm.nih.gov/pubmed/31080873

Cancer Res. 2019 May 16. pii: canres.3538.2018. doi: 10.1158/0008-5472.CAN-18-3538. A microfluidic chip enables isolation of exosomes and establishment of their protein profiles and associated signaling pathways in ovarian cancer. https://www.ncbi.nlm.nih.gov/pubmed/31097475

J Proteome Res. 2019 May 22. doi: 10.1021/acs.jproteome.9b00155. Proteomic Characterization of Immunoglobulin Content in Dermal Interstitial Fluid. https://www.ncbi.nlm.nih.gov/pubmed/31091412

Cell Syst. 2019 May 22;8(5):427-445.e10. doi: 10.1016/j.cels.2019.03.012. Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency. https://www.ncbi.nlm.nih.gov/pubmed/31078527

J Proteome Res. 2019 May 22. doi: 10.1021/acs.jproteome.9b00142. Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment. https://www.ncbi.nlm.nih.gov/pubmed/31090424

Front Cell Neurosci. 2019 Apr 26;13:163. doi: 10.3389/fncel.2019.00163. Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking. https://www.ncbi.nlm.nih.gov/pubmed/31080408

Sci Signal. 2019 May 14;12(581). pii: eaau0615. doi: 10.1126/scisignal.aau0615.The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1. https://www.ncbi.nlm.nih.gov/pubmed/31088976

Nat Commun. 2019 May 14;10(1):2162. doi: 10.1038/s41467-019-09883-7. IL-1β, IL-23, and TGF-β drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation. https://www.ncbi.nlm.nih.gov/pubmed/31089134

Nature. 2019 May 15. doi: 10.1038/s41586-019-1219-y. Progenitors from the central nervous system drive neurogenesis in cancer. https://www.ncbi.nlm.nih.gov/pubmed/31092925

Elife. 2019 May 14;8. pii: e39905. doi: 10.7554/eLife.39905. IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis. https://www.ncbi.nlm.nih.gov/pubmed/31084709

J Pharm Biomed Anal. 2019 May 1;172:357-363. doi: 10.1016/j.jpba.2019.04.052. Identification of recombinant human insulin and biosynthetic insulin analogues by multiplexed targeted unlabeled mass spectrometry of proteotypic tryptic peptides. https://www.ncbi.nlm.nih.gov/pubmed/31096094

Proc Natl Acad Sci U S A. 2019 May 16. pii: 201815166. doi: 10.1073/pnas.1815166116. Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation. https://www.ncbi.nlm.nih.gov/pubmed/31097591

EBioMedicine. 2019 May 8. pii: S2352-3964(19)30301-9. doi: 10.1016/j.ebiom.2019.04.062. Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders. https://www.ncbi.nlm.nih.gov/pubmed/31078522

Cell Chem Biol. 2019 Apr 11. pii: S2451-9456(19)30112-6. doi: 10.1016/j.chembiol.2019.03.016. Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells. https://www.ncbi.nlm.nih.gov/pubmed/31080076

J Assist Reprod Genet. 2019 May 15. doi: 10.1007/s10815-019-01444-7. Secretome profile selection of optimal IVF embryos by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. https://www.ncbi.nlm.nih.gov/pubmed/31093865

JCI Insight. 2019 May 16;4(10). pii: 125638. doi: 10.1172/jci.insight.125638. Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment. https://www.ncbi.nlm.nih.gov/pubmed/31092728

Mol Cell. 2019 May 13. pii: S1097-2765(19)30313-2. doi: 10.1016/j.molcel.2019.04.021. Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling. https://www.ncbi.nlm.nih.gov/pubmed/31101498

Mol Cell. 2019 May 17. pii: S1097-2765(19)30362-4. doi: 10.1016/j.molcel.2019.05.009. Lysosome Positioning Influences mTORC2 and AKT Signaling. https://www.ncbi.nlm.nih.gov/pubmed/31130364

Oncotarget. 2019 Apr 23;10(30):2855-2868. doi: 10.18632/oncotarget.26869. Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk. https://www.ncbi.nlm.nih.gov/pubmed/31080557

12 May 2019

J Proteomics Bioinform. 2019;12(2):38-42. doi: 10.4172/0974-276X.1000494. A Method for Isolation and Proteomic Analysis of Outer Membrane Vesicles from Fecal Samples by LC-MS/MS. https://www.ncbi.nlm.nih.gov/pubmed/31057293

Aging (Albany NY). 2019 May 9;11(9):2874-2888. doi: 10.18632/aging.101960. Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients. https://www.ncbi.nlm.nih.gov/pubmed/31076561

Clin Res Cardiol. 2019 May 6. doi: 10.1007/s00392-019-01480-4. Plasma protein biomarkers and their association with mutually exclusive cardiovascular phenotypes: the FIBRO-TARGETS case-control analyses. https://www.ncbi.nlm.nih.gov/pubmed/31062082

Innate Immun. 2019 May 8:1753425919846584. doi: 10.1177/1753425919846584. Immunophenotypic, cytotoxic, proteomic and genomic characterization of human cord blood vs. peripheral blood CD56Dim NK cells. https://www.ncbi.nlm.nih.gov/pubmed/31068047

Biotechnol Bioeng. 2019 May 8. doi: 10.1002/bit.27014. Multi-omics profiling of CHO parental hosts reveals cell line-specific variations in bioprocessing traits. https://www.ncbi.nlm.nih.gov/pubmed/31066037

J Pharmacol Exp Ther. 2019 May 6. pii: jpet.119.257097. doi: 10.1124/jpet.119.257097. Cellular Vesicles: New insights in engineering methods, interaction with cells and potential for brain targeting. https://www.ncbi.nlm.nih.gov/pubmed/31061141

Cell Chem Biol. 2019 Apr 8. pii: S2451-9456(19)30108-4. doi: 10.1016/j.chembiol.2019.03.012. Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. https://www.ncbi.nlm.nih.gov/pubmed/31056462

PLoS Pathog. 2019 May 9;15(5):e1007737. doi: 10.1371/journal.ppat.1007737. A streptococcal Fic domain-containing protein disrupts blood-brain barrier integrity by activating moesin in endothelial cells. https://www.ncbi.nlm.nih.gov/pubmed/31071198

J Proteome Res. 2019 May 22. doi: 10.1021/acs.jproteome.8b00903. An Integrated Analysis of Metabolites, Peptides, and Inflammation Biomarkers for Assessment of Preanalytical Variability of Human Plasma. https://www.ncbi.nlm.nih.gov/pubmed/31074987

Hepatology. 2019 May 9. doi: 10.1002/hep.30701. Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system. https://www.ncbi.nlm.nih.gov/pubmed/31070244

Elife. 2019 May 7;8. pii: e44187. doi: 10.7554/eLife.44187. An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma. https://www.ncbi.nlm.nih.gov/pubmed/31063128

Oncoimmunology. 2019 Mar 30;8(6):e1586042. doi: 10.1080/2162402X.2019.1586042. Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer. https://www.ncbi.nlm.nih.gov/pubmed/31069153

Microsyst Nanoeng. 2019 Feb 11;5:7. doi: 10.1038/s41378-019-0048-3. Microfluidic reactors for advancing the MS analysis of fast biological responses. https://www.ncbi.nlm.nih.gov/pubmed/31057934

Am J Gastroenterol. 2019 May;114(5):777-785. doi: 10.14309/ajg.0000000000000237. Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn’s Disease. https://www.ncbi.nlm.nih.gov/pubmed/31058681

J Natl Cancer Inst. 2019 May 11. pii: djz078. doi: 10.1093/jnci/djz078. Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas. https://www.ncbi.nlm.nih.gov/pubmed/31077320

Mol Cell. 2019 May 2. pii: S1097-2765(19)30310-7. doi: 10.1016/j.molcel.2019.04.018. R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation. https://www.ncbi.nlm.nih.gov/pubmed/31076284

5 May 2019

Mol Cell Proteomics. 2019 Apr 30. pii: mcp.RA118.001253. doi: 10.1074/mcp.RA118.001253. Hdac4 interactions in Huntington’s Disease viewed through the prism of multiomics. https://www.ncbi.nlm.nih.gov/pubmed/31040226

Blood Adv. 2019 May 14;3(9):1429-1440. doi: 10.1182/bloodadvances.2018030452. Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products. https://www.ncbi.nlm.nih.gov/pubmed/31053570

Proteomics Clin Appl. 2019 May 3:e1800185. doi: 10.1002/prca.201800185. Diagnostic Potential of Transferrin Glycoforms-A Lectin-Based Protein Microarray Approach. https://www.ncbi.nlm.nih.gov/pubmed/31050875

High Throughput. 2019 Apr 30;8(2). pii: E11. doi: 10.3390/ht8020011. Efficient Screening of Combinatorial Peptide Libraries by Spatially Ordered Beads Immobilized on Conventional Glass Slides. https://www.ncbi.nlm.nih.gov/pubmed/31052149

PLoS One. 2019 May 2;14(5):e0215927. doi: 10.1371/journal.pone.0215927. Development of a multiplex assay based on chimeric citrullinated peptides as proof of concept for diagnosis of rheumatoid arthritis. https://www.ncbi.nlm.nih.gov/pubmed/31048864

J Cell Biochem. 2019 Apr 30. doi: 10.1002/jcb.28799.Combining proteomics and bioinformatics to explore novel tegumental antigens as vaccine candidates against Echinococcus granulosus infection. https://www.ncbi.nlm.nih.gov/pubmed/31038784

J Am Coll Cardiol. 2019 May 7;73(17):2195-2205. doi: 10.1016/j.jacc.2019.01.074. Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics. https://www.ncbi.nlm.nih.gov/pubmed/31047008

Int J Biol Markers. 2019 May 1:1724600819841619. doi: 10.1177/1724600819841619. iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer. https://www.ncbi.nlm.nih.gov/pubmed/31041878

Cell. 2019 May 2;177(4):1035-1049.e19. Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities. https://www.ncbi.nlm.nih.gov/pubmed/31031003

Nature. 2019 May 1. doi: 10.1038/s41586-019-1173-8. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts.
https://www.ncbi.nlm.nih.gov/pubmed/31043742

Neurogenetics. 2019 Apr 30. doi: 10.1007/s10048-019-00578-1. A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity. https://www.ncbi.nlm.nih.gov/pubmed/31041561

Anal Chim Acta. 2019 Aug 27;1067:63-70. doi: 10.1016/j.aca.2019.03.033. Epub 2019 Mar 18. A multiplex liquid chromatography tandem mass spectrometry method for the quantification of seven therapeutic monoclonal antibodies: Application for adalimumab therapeutic drug monitoring in patients with Crohn’s disease. https://www.ncbi.nlm.nih.gov/pubmed/31047150

PLoS Comput Biol. 2019 Apr 30;15(4):e1006951. doi: 10.1371/journal.pcbi.1006951. I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment. https://www.ncbi.nlm.nih.gov/pubmed/31039157

J Crohns Colitis. 2019 May 4. pii: jjz090. doi: 10.1093/ecco-jcc/jjz090.Vitamin D inhibits pro-inflammatory T cell function in patients with inflammatory bowel disease. https://www.ncbi.nlm.nih.gov/pubmed/31051495

Bioact Mater. 2019 Apr 24;4:168-188. doi: 10.1016/j.bioactmat.2019.04.001. Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation.
https://www.ncbi.nlm.nih.gov/pubmed/31049466

Cell Stem Cell. 2019 May 2;24(5):812-820.e5. doi: 10.1016/j.stem.2019.02.006. Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-SpecificTranscription Factors Determine Cell Fate. https://www.ncbi.nlm.nih.gov/pubmed/30880026

Cell Rep. 2019 Apr 30;27(5):1528-1540.e7. doi: 10.1016/j.celrep.2019.04.010. Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues. https://www.ncbi.nlm.nih.gov/pubmed/31042478

Mol Neurobiol. 2019 Apr 29. doi: 10.1007/s12035-019-1613-3. S-Ketamine Reverses Hippocampal Dendritic Spine Deficits in Flinders Sensitive Line Rats Within 1 h of Administration. https://www.ncbi.nlm.nih.gov/pubmed/31037646

JCI Insight. 2019 May 2;4(9). pii: 98254. doi: 10.1172/jci.insight.98254. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. https://www.ncbi.nlm.nih.gov/pubmed/31045582

J Proteomics. 2019 Apr 30. pii: S1874-3919(19)30135-6. doi: 10.1016/j.jprot.2019.04.022. Decoding the human serum interactome of snake-derived antimicrobial peptide Ctn[15-34]: Toward an explanation for unusually long half-life.

Blood. 2019 May 1. pii: blood.2019000789. doi: 10.1182/blood.2019000789. Patterns of substrate affinity, competition and degradation kinetics underlie biological activity of thalidomide analogs. https://www.ncbi.nlm.nih.gov/pubmed/31043423

ACS Cent Sci. 2019 Apr 24;5(4):599-606. doi: 10.1021/acscentsci.8b00879. Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum.
https://www.ncbi.nlm.nih.gov/pubmed/31041379

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