TCR

Discovery of a Pan-Cancer Killing T Cell

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cancer-cell-and-t-cells

Crowther and colleagues screened clones of T cells isolated from a healthy donor and identified a clone (MC.7.G5) that recognized and killed many different types of cancer cells, including cells from solid tumors. When mixed with lung, melanoma, leukemia, breast, colon, prostate, bone, or ovarian cancer cell lines, MC.7.G5 released tumor necrosis factor (TNF) and … Read more

Fighting Cancer with the Immune System: Lessons from CAR T Cell Therapy

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CAR-T-cell-killing-cancer-cell-illustration

The Promise of CAR T Cell Therapy Many strategies that train the immune system to recognize and attack cancer are in development or undergoing clinical trials (1). However, these strategies have the potential to cause life-threatening consequences, as evidenced by the latest report of the death of another patient receiving CAR T cell therapy (2). CAR … Read more