Infection and Reactivation of Varicella Zoster Virus in Nerves

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This figure is from Depledge et al., Viruses 10, 349 (2018). Panel A shows infection of the sensory nerve (DRG) by the virus (VZV) through direct infection at the nerve endings or at the cell body by an infected T cell of the immune system. Panel B shows reactivation of viral replication and movement of the viral particles to the skin and possibly the spinal cord. Panel C shows a diagram of viral DNA in the neuronal cell body and detection of 2 distinct viral RNA molecules, VLT and ORF63, in sensory neurons infected with latent virus. Read more about shingles and chicken pox:
N. R. Gough, Prevent the pain, get the shingles vaccine. BioSerendipity (17 October 2018) https://www.bioserendipity.com/shingles-vaccines/

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