Antibody Glycosylation Remodeling

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antibody_glycosylation_remodeling

The schematics show an antibody with different patterns of glycosylation. Sugar moieties are indicated by differently colored shapes. The left schematic represents a glycosylation pattern that is frequently antigenic and produces allergic responses in patients. The right schematic shows different glycosylation patterns on the Fab and Fc portions of the antibody, eliminating antigenic patterns and improving therapeutic efficacy. Read more at
N. R. Gough, Building Better Antibodies. BioSerendipity (6 November 2018) https://www.bioserendipity.com/building-better-antibodies/.

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