Subcellular Locations of Sirtuins

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subcellular_location_SIRT

SIRT6 is a chromatin-modifying enzyme, SIRT7 is found in the nucleolus. SIRT1 is a chromatin-modifying enzyme that also shuttles from the nucleus to the cytoplasm, where it has multiple targets. SIRT2 is found in the cytoplasm. SIRT3, SIRT4, and SIRT5 are found in mitochondria.
Read more: N. R. Gough, Anti-Aging Supplements II: NAD+ as the Key to Healthy Aging. BioSerendipity (13 June 2018) https://www.bioserendipity.com/anti-aging-supplements-ii//

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