The left structure shows the basic helix-loop-helix region of MYC and MAX forming a heterodimer and binding to DNA. The right structure shows the homodimer of Omomyc, a MYC inhibitor, bound to DNA. Structures are from PDB. MYC-MAX-DNA, PDB ID: 1nkp; Omomyc-DNA, PDB ID: 5i50. Compilation by Nancy R. Gough, BioSerendipity
Read more: N. R. Gough, Context matters for targeting MYC in cancer. BioSerendipity 3 April 2019
https://www.bioserendipity.com/context-matters-for-targeting-myc-in-cancer/