A peptide inhibitor of the translocation of JNK and p38 into the nucleus prevents colitis in mice. The peptide interferes with the interaction between the kinases(blue octagons) and the importin proteins (orange triangles) that mediate transport through the nuclear pore. Mice given a chemical irritant that causes bowel inflammation were protected by administration of the peptide that blocked the kinase-importin interaction. Kinase activity (blue shading) in the nucleus was selectively blocked and activity in the cytosol was preserved. The left colon endoscopy image is from Klinikum Dritter Orden, München. Abteilung Innere Medizin I Vielen Dank an Christoph Kaiser für die Überlassung des Bildes zur Veröffentlichung! [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons. The right healthy colon image is from NIH. The figure is compiled by Nancy R. Gough, BioSerendipity.