Exposure of yeast to arsenic triggers ubiquitin tagging and lysosome degradation of sugar transporters, which are also responsible for letting arsenic into cells. Epidemiological studies have connected arsenic exposure to type 2 diabetes, and this may provide a mechanism.
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N. R. Gough, Yeast Study Links Arsenic to Diabetes through Glucose Transporters. BioSerendipity (15 April 2019)
https://www.bioserendipity.com/yeast-study-links-arsenic-to-diabetes-through-glucose-transporters/