SRC on the Outside

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Secreted proteins or the parts of transmembrane proteins that are extracellular can be phosphorylated. DeRita and colleagues reported that the cytosolic tyrosine kinase c-SRC was one of several kinases released from prostate cancer cells in exosomes. Sánchez-Pozo and colleagues identified a cancer-relevant function for extracellular c-SRC: c-SRC functioned outside of cultured cells to regulate the … Read moreSRC on the Outside

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Writing Tips: Words to Avoid

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One of the most common issues I encounter as an editor is the use of imprecise verbs in scientific research. It is possible that the author cannot be more precise, because the experiments have not been done to determine how the change occurred or because the conditions may produce diverse outcomes. However, these should be … Read moreWriting Tips: Words to Avoid

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TGF-β and Wnt Signaling Challenge the Concept of ‘a’ Pathway

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Researchers commonly refer to the molecular and biochemical events that occur in response to extracellular signals as pathways. There is a tendency to lump a related set of pathways into a general overarching pathway. For example, researchers may refer to the TGF-β pathway or the Wnt pathway. These are no more individual pathways than the … Read moreTGF-β and Wnt Signaling Challenge the Concept of ‘a’ Pathway

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